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KMID : 0914820140140030196
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Journal of the Korean Gastric Cancer Association
2014 Volume.14 No. 3 p.196 ~ p.203
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Expression Levels of Vascular Endothelial Growth Factors A and C in Patients with Peptic Ulcers and Gastric Cancer
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Shirin Taghizadeh
Mojtaba Sankian
Abolghasem Ajami
Mohsen Tehrani
Nasim Hafezi
Rajeeh Mohammadian
Touraj Farazmandfar
Vahid Hosseini
Ali Abbasi
Maryam Ajami
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Abstract
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Purpose: Vascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression levels of these two mol-ecules. We also analyzed the effect of Helicobacter pylori infection on VEGF-A and C expression levels.
Materials and Methods: Patients with dyspepsia who needed diagnostic endoscopy were selected and divided into three groups: non-ulcer dyspepsia (NUD), PUD, and GC, according to their endoscopic and histopathological results. Fifty-two patients with NUD, 50 with PUD, and 38 with GC were enrolled in this study. H. pylori infection was diagnosed by the rapid urease test. After RNA extraction and synthesis of cDNA, the expression levels of VEGF-A and C were determined by quantitative reverse transcriptase polymerase chain reac-tion.
Results: The VEGF-C expression level in the PUD and GC groups was significantly higher than that in the NUD group. Moreover, the VEGF-A expression level in the PUD and GC groups was higher than in the NUD group, although the differences were not statistically significant. Significant positive correlations were also observed between the expression levels of these two molecules in the PUD and GC groups. In addition, the expression levels of these two molecules were higher in H. pylori positive patients with PUD or GC than in H. pylori negative patients of the same groups; however, these differences did not reach statistical significance.
Conclusions: Up-regulation of VEGF-C expression during gastric mucosal inflammation may play a role in the development of peptic ul-cers or GC.
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KEYWORD
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Vascular endothelial growth factor-A, Vascular endothelial growth factor-C, Stomach neoplasms, Peptic ulcer, Helicobacter pylori
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